| A | |
| AA | Apollo Applications program |
| AAP | Apollo Applications Program |
| ABMA | Army Ballistic Missile Agency |
| AEC | Atomic Energy Commission |
| AEDC | Arnold Engineering Development Center |
| Aerojet | Aerojet General Corporation |
| AF | Air Force |
| All-Systems Vehicle | Non-flight stage used to checkout flight-worthiness of systems |
| AIAA | American Institute of Astronautics and Aeronautics |
| AMR | Atlantic Missile Range |
| AOMC | Army Ordnance Missile Command |
| Apollo | Project designation for manned lunar landing, also spacecraft for manned lunar landing |
| AS | Apollo/Saturn (specific payload and vehicle with a number, eg. AS-203) |
| ATM | Apollo Telescope Mount |
| B | |
| Battleship Stage | Non-flight stage replica for engine tests |
| BP | Boilerplate |
| "Bug" | Lunar excursion module, landing unit of the Apollo spacecraft |
| C | |
| C&SM | Command and Service Module |
| C-1 | Saturn C-1, early nomenclature for Saturn I |
| C-3 | Saturn C-3, Saturn configuration considered but not used |
| C-5 | Saturn C-5, configuration adopted for lunar landing Apollo flights (renamed Saturn V in February 1963) |
| C-IB | Saturn C-IB, vehicle selected in 1962 for manned earth orbital flights with full Apollo spacecraft (renamed Saturn IB) |
| Cape Canaveral | Launch site, name changed to Kennedy Space Center in 1963 |
| CCSD | Chrysler Corporation Space Division |
| CBTT | Common Bulkhead Test Tank |
| Chance-Vought | Saturn tank manufacturer, Dallas, Texas |
| Centaur | Vehicle for support of unmanned moon probes and other missions |
| CM | Command Module |
| Compromise | Later changed to Promise - barge transporter for Saturn boosters |
| CPFF | Cost-Plus-Fixed-Fee contract |
| CPIF | Cost-Plus-Incentive-Fee contract |
| D | |
| DAC | Douglas Aircraft Corporaton |
| DOD | Department of Defense |
| Downey | S&ID S-II stage component fabrication and testing facility location |
| Douglas | Douglas Aircraft Corporation |
| Dyna Soar | Air Force spacecraft for earth orbital flight featuring "glider reentry" |
| DX rating | Highest national priority |
| E | |
| EDS | Emergency Detection System |
| EFL | Edwards Field Laboratory |
| ESE | Electrical Support Equipment |
| EST | Eastern Standard Time |
| F | |
| FAA | Federal Aviation Agency |
| Fairchild Stratos | Meteoroid satellite contractor |
| F-1 engine | Saturn V booster (S-IC stage) engine |
| FRT | Flight Rating Tests |
| G | |
| GSE | Ground Support Equipment |
| H | |
| H-1 engine | Saturn I booster (S-I stage) engine |
| High Water Project | SA-2 and SA-3 experiment; water from dummy second stage was released into the ionosphere |
| Huntington Beach | DAC S-IVB assembly facility in California |
| I | |
| IBM | International Business Machine Corporation |
| IO | MSFC Industrial Operation organization |
| IU | Instrument Unit |
| J | |
| J-2 | Liquid hydrogen engine for S-IVB and S-II stages |
| JPL | Jet Propulsion Laboratory |
| K | |
| K | Thousands of pounds of thrust |
| KSC | Kennedy Space Center, was Cape Canaveral until November 28, 1963 |
| Kiwi-B | Nuclear reactor |
| L | |
| LaRC | Langley Research Center |
| LC | Launch Complex |
| LH2 | Liquid Hydrogen |
| LM | Lunar Module |
| LN | Liquid Nitrogen |
| LOC | Launch Operations Center |
| LOX | Liquid Oxygen |
| Lockheed | Lockheed Aircraft Company |
| LR-115 | First liquid hydrogen type engine (Pratt & Whitney), early designation of RL10-A-3 engine |
| LR-119 | Proposed uprated LR-115 engine (project was cancelled) |
| LSSM | Local Scientific Survey Module |
| LTV | Ling-Temco-Vought |
| LV | Launch Vehicle |
| LVDC | Launch Vehicle Digital Computer |
| M | |
| McDonnell Douglas Corporation | Douglas Aircraft Company merged with McDonnell Aircraft Corporation, April 1967 |
| MAF | Michoud Assembly Facility (formerly Michoud Operations) |
| Martin | Martin Company |
| ME | MSFC's Manufacturing Engineering Laboratory |
| Michoud | NASA's Michoud Operations |
| Minneapolis-Honeywell | Minneapolis-Honeywell Incorporated name changed to Honeywell Incorporated |
| ML | Mobile Launcher |
| MSC | Manned Spacecraft Center |
| MSFC | George C. Marshall Space Flight Center |
| MSS | Mobile Service Structure |
| MSTS | Military Sea Transport Services |
| MTF | Mississippi Test Facility (at one time MTO) in Hancock County, Mississippi |
| N | |
| NAA | North American Aviation, Inc. |
| NAR | North American Rockwell Corporation (name resulting from merger of NAA, Inc. and Rockwell-Standard Corp. Sept. 22, 1967) |
| NASA | National Aeronautics and Space Administration |
| NERVA | Nuclear engine for RIFT stage |
| NOVA | Moon direct flight vehicle deferred in favor of Saturn V |
| P | |
| P&VE | Proulsion and Vehicle Engineering Laboratory at MSFC |
| PCS | Pointing Control System |
| Pegasus | Meteoroid detection satellite |
| PFRT | Preliminary Flight Rating Test |
| P&W | Pratt & Whitney Company |
| R | |
| R&D | Research and Development |
| RCA | Radio Corporation of America |
| Rocketdyne | Division of North American Aviation |
| RIFT | Reactor-In-Flight Test stage (nuclear power) |
| RP-1 | A kerosene-type fuel |
| RL10-A-3 | Liquid hydrogen engine for S-IV stage |
| S | |
| S&ID | Space and Information Systems Division of North American Aviation |
| SA | Saturn I launch vehicle (with number signifies a specific vehicle such as SA-5) |
| S-I | Saturn I originally Saturn C-1 first stage |
| S-II | Saturn V second stage |
| S-IVB | Saturn V third stage |
| S-IC | Saturn V first stage |
| S-IV | Saturn I second stage |
| SACTO | Douglas Aircraft's Sacramento Test Facility |
| Santa Susana | Test site for S-II and S-IVB stage and J-2 engine |
| Santa Monica | Douglas Aircraft's fabrication facility at Santa Monica, California |
| Saturn I | Two-stage vehicle, with eight H-1 engines in first stage and six RL10 engines in second stage |
| Saturn IB | Two-stage vehicle, with eight H-1 engines in first stage and single J-2 engine in second stage |
| Saturn V | Three stage vehicle, with five F-1 engines in first stage, five J-2 engines in second stage, and single J-2 engine in third stage |
| Seal Beach | North American Aviation Assembly plant at Seal Beach, California |
| SLCC | Saturn Launch Control Computer |
| Slidell | A computer center that serves Michoud in Slidell, La. |
| SM | Service Module |
| SPS | Service Propulsion System |
| SRM | Solid Rocket Motor |
| SSFL | Santa Susana Field Laboratory |
| SSO | Saturn Systems Office |
| Sverdrup Parcell Company | Mississippi Test Facility design contractor |
| U | |
| Uprated Saturn | Nomenclature used for S-IB for a short period of time |
| V | |
| VAB | Vertical (Vehicle) Assembly Building |
| VCL | Vehicle Checkout Laboratory |