- Deputy Associate Administrator, Office of Space Science and Applications (Oran W. Nicks)
- Deputy Associate Administrator (Science), Office of Space Science and Applications (Henry J. Smith)
- Deputy Associate Administrator (Engineering), Office of Space Science and Applications (Vincent L. Johnson)
- Deputy Associate Administrator (Applications), Office of Space Science and Applications (Leonard Jaffe; added 1970)
- Director, Advanced Programs (Pitt Thorne; Robert G. Wilson, 1970)
- Director, Program Review and Resources Management (Eldon D. Taylor; Richard L. Daniels, 1971)
- Director, Bioscience Programs (Orr E. Reynolds; Benny B. Hall, acting, late 1970; office reorganized as part of OMSF in early 1971)
- Deputy Director, Bioscience Programs (B. Hall)
- Assistant Director (Science), Bioscience Programs (D. Jenkins)
- Program Chief, Advanced Programs and Technology (Loyal G. Goff)
- Program Manager, Biosatellite (T. Dallow)
- Program Chief, Exobiology (S. Young)
- Program Chief, Environmental Biology (J. Saunders)
- Program Chief, Physical Biology (G. Jacobs)
- Program Chief, Planetary Quarantine (L. Hall)
- Director, Space Applications Program (Leonard Jaffe; dropped as a program office in 1970; Jaffe became Deputy Assoc. Admin. for Applications; reorganized as two program offices - Communications and Earth Observations)*
- Director, Communications Programs (R. B. Marsten; added 1970; see also above) Director, Earth Observations Program (John M. DeNoyer; added 1970; see also above)
- Director, Launch Vehicle and Propulsion Programs (Joseph B. Mahon)**
- Director, Planetary Programs (Hearth; Robert S. Kraemer, 1971)
- Assistant Director, Planetary Programs (Donald G. Rea)
- Program Manager, Advanced Programs and Technology (Robert Kraemer)
- Program Manager, Surface Lab. Science (Milton A. Mitz)
- Program Manager, Lunar Orbiter (Lee Scherer)
- Program Manager, Mariner V (Glenn Reiff)
- Program Manager, Mariner 69 (N. Cunningham)
- Program Manager, Mariner Mars 71 (Carl W. Glahn)
- Program Manager, Pioneer Program (Reiff)
- Program Chief, Planetary Astronomy (W. Brunk)
- Program Chief, Planetary Atmospheres (R. Fellows)
- Program Chief, Planetology (E. Dwornik)
- Deputy Associate Administrator, Office of Space Science (V. Johnson; vacant, fall of 1974; John M. Thole, late 1974; Anthony J. Calio, fall 1975; Andrew J. Stofan, 1977)
- Deputy Associate Administrator (Science), Office of Space Science (H. Smith; Ichtiaque Rasool, fall 1975)
- Deputy Associate Administrator (Engineering), Office of Space Science (Milton W. Rosen; added spring 1973; dropped fall 1975; dropped 1977)
- Director, Advanced Programs (Wilson; dropped 1974)
- Director, Program Review and Resource Management/Program Analysis (Daniels; Charles Wash, 1976)
- Director, Launch Vehicle and Propulsion Programs (Mahon; office reorganized as part of OMSF in spring 1976 and renamed Office of Expendable Launch Vehicles)**
- Director, Planetary Programs (Kraemer; A. Thomas Young, 1976)
- Director, Physics and Astronomy/Astrophysics (Mitchell; Alois W. Schardt, fall 1973; T. B. Norris, 1976)
- Director, Lunar Programs (William T. O'Bryant; added spring 1973; Noel W. Hinners, acting, late 1974; Edward A. Flinn; early 1975; dropped 1976)
- Director, Life Sciences Programs (Winter; moved from OMSF early 1976; Gerald A. Soffen, acting, late 1978)
- Director, Solar Terrestrial Programs (Harold Glaser; added early 1976)
- Director, Physics and Astronomy Programs (Jesse Mitchell)
- Deputy Director, Physics and Astronomy Programs (Mitchell, acting)
- Program Chief, Advanced Programs and Technology (Marcel J. Ancremanne, acting)
- Program Manager, Astronomical Observatories (C. Ashworth)
- Program Manager, Explorers and Sounding Rockets (J. Holtz)
- Program Manager, Geophysical Observatories (T. Fischetti)
- Chief, Astronomy (Nancy Roman)
- Chief, Interplanetary Dust and Cometary Physics (M. Dubin)
- Chief, Ionospheric Physics (E. Schmerling)
- Chief, Particles and Fields (Alois W. Schardt)
- Chief, Solar Physics (N. Glaser)
- Director, Upper Atmospheric Research (James King, Jr.; added early 1976; Lawrence R. Greenwood, fall 1976; dropped 1977)
*See chapter 4 for a discussion of the management of space applications programs.
**See chapter 2 for a discussion of the management of launch vehicle programs.